Recent publications

• Tissue Engineering: 3D Printed Stackable Titer Plate Inserts Supporting Three Interconnected Tissue Models for Drug Transport Studies. (Adv. Biosys). 7/2020). Morten Leth Jepsen  Andreas Willumsen  Chiara Mazzoni  Anja Boisen  Line Hagner Nielsen  Martin Dufva. 2020, Volume 4, Issue 7, pp. 1900289. https://doi.org/10.1002/adbi.201900289

• Jepsen ML, Nielsen LH, Boisen A, Almdal K, Dufva M. Characterization of thin gelatin hydrogel membranes with balloon properties for dynamic tissue engineering. Biopolymers. 2019;110(1):e23241. doi:10.1002/bip.23241. https://doi.org/10.1002/bip.23241

• Tan H-Y, Trier S, Rahbek UL, Dufva M, Kutter JP, Andresen T A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies. PLoS. 2018;13(5):e0197101. https://doi.org/10.1371/journal.pone.0197101
  

• Starokozhko V, Hemmingsen M, Larsen L, et al. Differentiation of human-induced pluripotent stem cell under flow conditions to mature hepatocytes for liver tissue engineering. J Tissue Eng Regen Med. 2018

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  Pimentel C R, Ko SK, Caviglia C, Wolff A, Emnéus J, Keller SS, Dufva M.  Three-dimensional fabrication of thick and densely populated soft constructs with complex and actively perfused channel network. 2018. Acta Biomaterialia, 65, 174-184. https://doi.org/10.1016/j.actbio.2017.10.047

  ;12(5):1273-1284. https://doi.org/10.1002/term.2659

Recent publications

• Kajtez J, Radeke C, Lind JU, Emnéus J. Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs. Vis. Exp. (195), e65158, doi:10.3791/65158 (2023).
• Pless CJ, Nikzad S, Papiano I, Gnanadass S, Kadumudi FB, Dolatshahi‐Pirouz A, Thomsen CE, Lind JU. Soft Electronic Block Copolymer Elastomer Composites for Multi‐Material Printing of Stretchable Physiological Sensors on Textiles. Advanced Electronic Materials. Volume 9, Issue 5, May 2023. https://doi.org/10.1002/aelm.202201173
• Radeke C, Pons R, Mihajlovic M, Knudsen JR, Butdayev S, Kempen PJ, Segeritz C-P, Andresen TL, Pehmøller CK, Jensen TE, Lind JU. Transparent and Cell-Guiding Cellulose Nanofiber 3D Printing Bioinks. ACS Applied Materials & Interfaces. Volume 15, Issue 2, January 2023. https://doi.org/10.1021/acsami.2c16126
• Kajtez J, Wesseler MF, Birtele M, Riyahi Khorasgani F, Rylander Ottosson D, Heiskanen A, Kamperman T, Leijten J, Martínez‐Serrano A, Larsen NB, Angelini TE, Parmar M, Lind JU, Emnéus J. Embedded 3D printing in self‐healing annealable composites for precise patterning of functionally mature human neural constructs. Advanced Science. Volume 9, Issue 25, September 2022.

  https://doi.org/10.1002/advs.202201392

• Youhanna S, Kemas AM, Preiss L, Zhou Y, Shen JX, Cakal SD, Paqualini FS, Goparaju SK, Zandi Shafagh R, Lind JU, Sellgren CM, Lauschke VM. Organotypic and microphysiological human tissue models for drug discovery and development—current state-of-the-art and future perspectives. Pharmacological Reviews. Volume 74, Issue 1, January 2022.

  https://doi.org/10.1124/pharmrev.120.000238

Recent publications

• Ristori T, Stassen OMJA, Sahlgren CM, Loerakker S. Lateral Induction Limits the Impact of Cell Connectivity on Notch Signaling in Arterial Walls. Int J Numer Method Biomed Eng. 2020. https://doi.org/10.1002/cnm.3323
• van Engeland NCA#, Suarez Rodriguez F#, Rivero-Müller A, Ristori T, Duran CL, Stassen OMJA, Antfolk D, Driessen RCH, Ruohonen S, Ruohonen ST, Nuutinen S, Savontaus E, Loerakker S, Bayless KJ, Sjöqvist M, Bouten CVC, Eriksson JE, Sahlgren CM. Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress. Sci Rep. 2019. https://doi.org/10.1038/s41598-019-48218-w 

• Driessen RCH, Stassen OMJA, Sjöqvist M, Suarez Rodriguez F, Grolleman J, Bouten CVC, Sahlgren CM. Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1. Integr Biol (Camb). 2018. https://doi.org/10.1039/c8ib00036k

• van Engeland NCA, Pollet AMAO, den Toonder JMJ, Bouten CVC, Stassen OMJA, Sahlgren CM. A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions. Lab Chip. 2018. https://doi.org/10.1039/c8lc00286j

• Loerakker S*, Stassen OMJA, Ter Huurne FM, Boareto M, Bouten CVC, Sahlgren CM*. Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis. Proc Natl Acad Sci U S A. 2018. https://doi.org/10.1073/pnas.1715277115 

Recent publications

• Mäntylä E, Montonen T, Azzari L, Mattola S, Hannula M, Vihinen-Ranta M, Hyttinen J, Vippola M, Foi A, Nymark S, Ihalainen TO. Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina. Molecular Biology of the CellVol. 34, No. 9, https://doi.org/10.1091/mbc.E22-09-0448
• Tervonen A, Korpela S, Nymark S, Hyttinen J, Ihalainen TO. The Effect of Substrate Stiffness on Elastic Force Transmission in the Epithelial Monolayers over Short Timescales. Cellular and Molecular Bioengineering (2023), https://doi.org/10.1007/s12195-023-00772-0
• Ahtiainen A, Annala I, Rosenholm M, Kohtala S, Hyttinen J, Tanskanen JMA, Rantamäki T. Ketamine reduces electrophysiological network activity in cortical neuron cultures already at sub-micromolar concentrations – Impact on TrkB-ERK1/2 signaling. Neuropharmacology, Volume 229, 2023, https://doi.org/10.1016/j.neuropharm.2023.109481
• Forouzandehmehr M, Paci M, Koivumäki JT, Hyttinen J. Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights. Physiol., 31 October 2022, Sec. Computational Physiology and Medicine, Volume 13 – 2022, https://doi.org/10.3389/fphys.2022.1010786
• Barros MT, Siljak H, Mullen P, Papadias C, Hyttinen J, Marchetti N. Objective Supervised Machine Learning-Based Classification and Inference of Biological Neuronal Networks. Molecules. 2022; 27(19):6256, https://doi.org/10.3390/molecules27196256

Recent publications

• Tornberg K, Välimäki H, Valaskivi S, Mäki A-J, Jokinen M, Kreutze, J, Kallio P. Compartmentalized Organ-on-a-chip Structure for Spatiotemporal Control of Oxygen Microenvironments. Biomedical Microdevices. Volume: 24, Issue: 34. October 2022. https://doi.org/10.1007/s10544-022-00634-y
• Karttu A, Lahtonen K., Heikkilä J., Väliaho J., Narkilahti S., Lekkala J, Kallio P. Corrosion and Protection of Silicon Nitride Insulators in Microelectrode Array Applications. IEEE Sensors Journal. Volume: 22, Issue: 13, July 2022, pp. 12504-12514, DOI 10.1109/JSEN.2022.3178640 https://ieeexplore.ieee.org/document/9788528
• Skogberg A, Siljander S, Mäki A-J, Honkanen M, Efimov A, Hannula M, Lahtinen P, Björkqvist T, Tuukkanen S, Kallio P. Self-assembled Cellulose Nanofiber-Carbon Nanotube Nanocomposite Films with Anisotropic Conductivity. November 2021. DOI: 10.1039/d1nr06937c https://pubs.rsc.org/en/content/articlelanding/2022/nr/d1nr06937c
• Gaballa M, Penttinen P, Kreutzer J, Mäki A, Kallio P, Aalto-Setälä K. Cardiac Ischemia on-a-chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human Induced Pluripotent Stem Cell-derived Cardiomyocytes.

  Cells, Volume 11, Issue 6, p. 1045. March 2022. DOI: 10.3390/cells11061045 https://www.mdpi.com/2073-4409/11/6/1045

• Ristola M, Fedele C, Hagman S, Sukki L, Kapucu EF, Mzezeva R, Hyvärinen T, Kallio P, Priimagi A, Narkilahti, S. Directional Growth of Human Neuronal Axons in a Microfluidic Device with Nanotopography on Azobenzene-Based Material. Advanced Materials Interfaces. Volume 8, Issue 11, May 2021. https://doi.org/10.1002/admi.202100048

Recent publications

• Rangasami, VK, Nawale, G, Asawa, K, Kadekar, S, Samanta, S, Nilsson, B et al.. Pluronic Micelle-Mediated Tissue Factor Silencing Enhances Hemocompatibility, Stemness, Differentiation Potential, and Paracrine Signaling of Mesenchymal Stem Cells. Biomacromolecules. 2021;22 (5):1980-1989. doi: 10.1021/acs.biomac.1c00070. PubMed PMID:33813822 PubMed Central PMC8154246.

• Bakreen, A, Juntunen, M, Dunlop, Y, Ugidos, IF, Malm, T, Miettinen, S et al.. Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats. Int J Mol Sci. 2021;22 (4):. doi: 10.3390/ijms22041512. PubMed PMID:33546370 PubMed Central PMC7913568

• Juntunen, M, Hagman, S, Moisan, A, Narkilahti, S, Miettinen, S. In Vitro Oxygen-Glucose Deprivation-Induced Stroke Models with Human Neuroblastoma Cell- and Induced Pluripotent Stem Cell-Derived Neurons. Stem Cells Int. 2020;2020 :8841026. doi: 10.1155/2020/8841026. PubMed PMID:33178286 PubMed Central PMC7647751.

• Hyväri, L, Vanhatupa, S, Halonen, HT, Kääriäinen, M, Miettinen, S. Myocardin-Related Transcription Factor A (MRTF-A) Regulates the Balance between Adipogenesis and Osteogenesis of Human Adipose Stem Cells. Stem Cells Int. 2020;2020 :8853541. doi: 10.1155/2020/8853541. PubMed PMID:33029150 PubMed Central PMC7527895.
• Tamminen, I, Lehto, K, Hannula, M, Ojansivu, M, Johansson, L, Kellomäki, M et al.. A tube-source X-ray microtomography approach for quantitative 3D microscopy of optically challenging cell-cultured samples. Commun Biol. 2020;3 (1):548. doi: 10.1038/s42003-020-01273-w. PubMed PMID:33009501 PubMed Central PMC7532209.

Recent publications

• The material-enabled oxygen control in thiol-ene microfluidic channels and its feasibility for subcellular drug metabolism assays under hypoxia in vitro, Lab Chip, 2021, 21, 1820-1831.
  Kiiski, I., Järvinen, P., Ollikainen, E., Jokinen, V., Sikanen, T.M.
• Simultaneous Culturing of Cell Monolayers and Spheroids on a Single Microfluidic Device for Bridging the Gap between 2D and 3D Cell Assays in Drug Research, Adv. Funct. Mater. 2020, 2000479 (11 pp).
  Järvinen, P., Bonabi, A., Jokinen, V., Sikanen, T.M.
• Cell Proliferation on Common 3D Printing Materials Used in Stereolithography of Microfluidic Devices, Lab Chip 2020, 20, 2372 – 2382.
  Piironen, K., Haapala, M., Talman, V., Järvinen, P., Sikanen, T.M.
• Digital microfluidics-enabled analysis of individual variation in liver cytochrome P450 activity”, Anal. Chem., 2020, 92, 14693–14701.
  Sathyanarayanan, G., Haapala, M., Sikanen, T.M.
• Overcoming the Pitfalls of Cytochrome P450 Immobilization Through the Use of Fusogenic Liposomes, Adv. Biosyst. 2019, 3, 3, 1800245 (6 pp).
  Kiiski, I., Pihlaja, T., Urvas, L., Witos, J., Wiedmer, S.K., Jokinen, V.P., Sikanen, T.M.
  

Recent publications

• Alsaed B,…Saharinen P, Ilonen I, Haikala HM: Ex vivo modeling of precision immuno-oncology responses in lung cancer organ-on-a-chip. Under prep.

• Ollila-Raj H, Murumägi A, Pellinen T, Arjama M, Sutinen E, Volmonen K, Haikala HM, Kallioniemi O, Mäyränpää MI, Ilonen I. Novel therapeutic approaches for pleural mesothelioma identified by functional ex vivo drug sensitivity testing. Lung Cancer. Apr;178:213-219, 2023  

• Haikala HM, Lopez T, Köhler J, Eser PO, Xu M, Zeng Q, Teceno TJ, Ngo K, Zhao Y, Ivanova EV, Bertram AA, Leeper BA, Chambers ES, Adeni AE, Taus LJ, Kuraguchi M, Kirschmeier PT, Yu C, Shiose Y, Kamai Y, Qiu Y, Paweletz CP, Gokhale PC, Jänne PA. EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd. Cancer Res. Jan 1;82(1):130-141, 2022 

• Haikala HM, Jänne PA. Thirty Years of HER3: From Basic Biology to Therapeutic Interventions. Clin Cancer Res. 2021 Jul 1;27(13):3528-3539, 2021 

• Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schüler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkilä P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefström J. Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nat Commun. Feb 6;10(1):620, 2019 

Recent publications

• Valtonen J, Prajapati C, Cherian RM, Vanninen S, Ojala M, Leivo K, Heliö T, Koskenvuo J, Aalto-Setälä K. The Junctophilin-2 Mutation p.(Thr161Lys) Is Associated with Hypertrophic Cardiomyopathy Using Patient-Specific iPS Cardiomyocytes and Demonstrates Prolonged Action Potential and Increased Arrhythmogenicity. 2023 May 27;11(6):1558. doi: 10.3390/biomedicines11061558. PMID: 37371654; PMCID: PMC10295168.
• Gaballah M, Penttinen K, Kreutzer J, Mäki AJ, Kallio P, Aalto-Setälä K. Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. 2022 Mar 19;11(6):1045. doi: 10.3390/cells11061045. PMID: 35326497; PMCID: PMC8947267.
• Alexanova A, Raitoharju E, Valtonen J, Aalto-Setälä K, Viiri LE. Coronary artery disease patient-derived iPSC-hepatocytes have distinct miRNA profile that may alter lipid metabolism. Sci Rep. 2023 Jan 30;13(1):1706. doi: 10.1038/s41598-023-28981-7. PMID: 36717592; PMCID: PMC9886909.
• Häkli M, Kreutzer J, Mäki AJ, Välimäki H, Cherian RM, Kallio P, Aalto-Setälä K, Pekkanen-Mattila M. Electrophysiological Changes of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes during Acute Hypoxia and Reoxygenation. Stem Cells Int. 2022 Dec 19;2022:9438281. doi: 10.1155/2022/9438281. PMID: 36579142; PMCID: PMC9792238.
• Maria Cherian R, Prajapati C, Penttinen K, Häkli M, Koivisto JT, Pekkanen-Mattila M, Aalto-Setälä K. Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays. Cell Biol Toxicol. 2023 Feb;39(1):145-163. doi: 10.1007/s10565-022-09742-0. Epub 2022 Jul 23. PMID: 35870039; PMCID: PMC10042918.
  

Recent publications

• Lotila J, Hyvärinen T, Skottman H, Airas L, Narkilahti S, Hagman S. Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient. Stem Cell Res. 2022;63 :102865. doi: 10.1016/j.scr.2022.102865. PubMed PMID:35843021 .
• Hyvärinen T, Hagman S, Ristola M, Sukki L, Veijula K, Kreutzer J et al.. Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system. Sci Rep. 2019;9 (1):16944. doi: 10.1038/s41598-019-53414-9. ubMed PMID:31729450 PubMed Central PMC6858358.
• Ristola M, Fedele C, Hagman S, Sukki L, Kapucu E, Mzezewa R, Hyvärinen T, Kallio P, Priimägi A, Narkilahti S. Directional Growth of Human Neuronal Axons in a Microfluidic Device with Nanotopography on Azobenzene-Based Material. Advanced Biomaterial Interfaces 2021 DOI: 10.1002/admi.202100048 (Open access))
• Mzezewa R, Lotila J, Kiiski H, Vinogradov A, Kapucu FE, Peltola J, Hagman S, Narkilahti S.  A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity. Stem Cell Res. 2022;60 :102665. doi: 10.1016/j.scr.2022.102665. PubMed PMID:35091307.
• Juntunen M, Hagman S, Moisan A, Narkilahti S, Miettinen S. In Vitro Oxygen-Glucose Deprivation-Induced Stroke Models with Human Neuroblastoma Cell- and Induced Pluripotent Stem Cell-Derived Neurons. Stem Cells Int. 2020;2020 :8841026. doi: 10.1155/2020/8841026. PubMed PMID:33178286 PubMed Central PMC7647751.

Recent publications

• Isosaari L, Vuorenpää H, Yrjänäinen A, Kapucu FE, Kelloniemi M, Pakarinen T-K, Miettinen S, Narkilahti S. Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types. Cell Commun Signal 21, 132 (2023). https://doi.org/10.1186/s12964-023-01159-4
• Mörö A, Samanta S, Honkamäki L, Rangasami VK, Puistola P, Kauppila M, Narkilahti S, Miettinen S, Oommen O, Skottman H. Hyaluronic acid based next generation bioink for 3D bioprinting of human stem cell derived corneal stromal model with innervation. 2022 Dec 29;15(1). doi: 10.1088/1758-5090/acab34.
• Räsänen N, Harju V, Joki T, Narkilahti S. Practical guide for preparation, computational reconstruction and analysis of 3D human neuronal networks in control and ischaemic conditions. Development (2022) 149 (20): dev200012. https://doi.org/10.1242/dev.200012
• Häkli M, Jäntti S Joki T, Sukki L, Tornberg K, Aalto- Setälä K, Kallio P, Pekkanen-Mattila M, Narkilahti S. Human neurons form axon mediated functional connections with human cardiomyocytes in compartmentalized microfluidic chip. J. Mol. Sci. 2022, 23(6), 3148; https://doi.org/10.3390/ijms23063148
• Kapucu FE, Vinogradov A, Hyvärinen T, Aarnos L, Ylä-Outinen L, Narkilahti S. Comparative microelectrode array data of functional development of human PSC-derived and rat neuronal networks. Scientific Data 2022, 9:120, https://doi.org/10.1038/s41597-022-01242-4

Recent publications

• Thermoplastic elastomer (TPE) – Poly-(methyl methacrylate) (PMMA) hybrid devices for active pumping PDMS-free Organ-on-a-Chip systems. Biosensors 2021, 11(5), 162. Mathias Busek, Steffen Nøvik, Aleksandra Aizenshtadt, Mikel Amirola-Martinez, Thomas Combriat, Stefan Grünzner, Stefan Krauss

• Pre-clinical lead optimization of a 1,2,4-triazole based tankyrase inhibitor. J Med Chem. 2020, Jul 9;63(13):6834-6846. Jo Waaler, Ruben G. G. Leenders, Sven T. Sowa, Shoshy Alam Brinch, Max Lycke, Piotr Nieczypor, Sjoerd Aertssen, Sudarshan Murthy, Albert Galera-Prat, Eddy Damen, Anita Wegert, Marc Nazaré, Lari Lehtiö, and Stefan Krauss

• 3D cell culture models and organ‐on‐a‐chip: Meet separation science and mass spectrometry. Electrophoresis 2020, 41 (1-2), 56-64. Ann Lin, Frøydis Sved Skottvoll, Simon Rayner, Stig Pedersen‐Bjergaard, Gareth Sullivan, Stefan Krauss, Steven Ray Wilson, Sean Harrison

• Pancreas-on-a-chip technology for transplantation applications. Current Diabetes Reports 2020, 20 (12), 1-13. Shadab Abadpour; Aleksandra Aizenshtadt; Petter Angell Olsen; Kayoko Shoji; Steven Ray Wilson; Stefan Krauss; Hanne Scholz

• The tankyrase inhibitor G007-LK inhibits small intestine Lgr5+ stem cell proliferation without altering tissue morphology. Biol Res. 2018, Jan 9;51(1):3. Jens Henrik Norum, Ellen Skarpen, Andreas Brech, Raoul Kuiper, Wanja Kildal, Jo Waaler, Stefan Krauss and Therese Sørlie

Recent publications

• Håti, A.G., Basset, D., Ribe, J.M., Sikorski, P., Weitz, D.A., and Stokke, B.T. Versatile, cell and chip friendly method to gel alginate in microfluidic devices. Lab on a Chip 16 (2016) 3718-3727.

• Jonasova, E.P., Bjørkøy, A., and Stokke, B.T., Toehold length of target ssDNA affects its reaction-diffusion behaviour in DNA-responsive DNA-co-acrylamide hydrogels; Biomacromolecules, 21 (2020) 1687-1699

• Øvreeide, I.H., Zoellner, A., Mielnik, M.M. and Stokke, B.T. Curved passive mixing structures: A robust design to obtain efficient mixing and mass transfer in microfluidic channels. J. Micromech. Microeng. 31 (2021) 015006

• Ahmed, H., and Stokke, B.T., Fabrication of monodisperse alginate microgel beads by microfluidic picoinjection: A chelate free approach.  Lab on Chip 21 (2021) 2232-2243

• Wong CFA, Vliet, L. D., Bhujbal SV, Guo, C., Sletmoen M., Stokke BT, Hollfelder, F., and Lale R. A titratable cell lysis-on-demand system for droplet-compartmentalized ultrahigh-throughput screening in functional metagenomics and directed evolution. ACS Synthetic Biology (2021, in press)

Recent publications

• Skottvoll, S. F., Hansen, F. A., Harrison, S., Boger, I. S., Mrsa, A., Restan, M. S., Stein, M., Lundanes, E., Pedersen-Bjergaard, S., Aizenshtadt, A., Krauss, S., Sullivan, G., Bogen, I. L, Wilson, S. R. Electromembrane extraction and mass spectrometry for liver organoid drug metabolism studies. Analytical chemistry 93 (7), 3576-3585 (2021)
• Røberg-Larsen, H., Lundanes, E., Nyman, T.A., Berven, F.S., Wilson, S.R. Liquid chromatography, a key tool for the advancement of single-cell omics analysis. Analytica Chimica Acta, 338551 (2021).
• Roberg-Larsen, H., Wilson, S.R., Lundanes, E. Recent advances in on-line upfront devices for sensitive bioanalytical nano LC methods. TrAC Trends in Analytical Chemistry, 116190 (2021).

• Kogler, S., Harrison, S., Aizenshtadt, A., Skottvoll, F.S., Abadpour, S., Krauss, S., Scholz, H., Sullivan, G., Lundanes, E., Wilson, S.R. “Organoid-in-a-column” coupled on-line with liquid chromatography-mass spectrometry. bioRxiv (2020).

• Harrison, S., Sillar, R., Tanaka, Y. et al. Scalable production of tissue-like vascularised liver organoids from human PSCs. bioRxiv (2020)

Recent publications

• Jiang X, Bergquist A, Löscher BS, Venkatesh G, Mold JE, Holm K, Laerdahl JK, Skånland SS, Maleki KT, Cornillet M, Taskén K, Franke A, Karlsen TH, Björkström NK, Melum E (2021) A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis.Sci Transl Med, 13 (582) DOI 10.1126/scitranslmed.abb0036, PubMed 33627483

• Sampaziotis F, Muraro D, Tysoe OC, Sawiak S, Beach TE, Godfrey EM, Upponi SS, Brevini T, Wesley BT, Garcia-Bernardo J, Mahbubani K, Canu G, Gieseck R, Berntsen NL, Mulcahy VL, Crick K, Fear C, Robinson S, Swift L, Gambardella L, Bargehr J, Ortmann D, Brown SE, Osnato A, Murphy MP et al. (2021) Cholangiocyte organoids can repair bile ducts after transplantation in the human liver.
  Science, 371 (6531), 839-846
  DOI 10.1126/science.aaz6964, PubMed 33602855

• Valestrand L, Berntsen NL, Zheng F, Schrumpf E, Hansen SH, Karlsen TH, Blumberg RS, Hov JR, Jiang X, Melum E (2020) Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells.
  Clin Exp Immunol, 203 (2), 304-314 DOI 10.1111/cei.13541, PubMed 33089489

• Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS (2019) Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Nat Immunol, 20 (12), 1644-1655 DOI 10.1038/s41590-019-0504-0, PubMed 31636468

• Berntsen NL, Fosby B, Tan C, Reims HM, Ogaard J, Jiang X, Schrumpf E, Valestrand L, Karlsen TH, Line PD, Blumberg RS, Melum E (2018)
  Natural killer T cells mediate inflammation in the bile ducts. Mucosal Immunol, 11 (6), 1582-1590
  DOI 10.1038/s41385-018-0066-8, PubMed 30115993

Recent publications

• Abadpour, S., Wang, C., Niemi, E.M. et al. Tissue Engineering Strategies for Improving Beta Cell Transplantation Outcome. Curr Transpl Rep (2021). https://doi.org/10.1007/s40472-021-00333-
• Ghila L, Legøy TA, Mathisen AF, Abadpour S, Paulo JA, Scholz H, Ræder H, Chera S. Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors. Int J Mol Sci. 2:22(7) (2021), 3698. 
• Abadpour S, Tyrberg B, Schive SW, Huldt CW, Gennemark P, Ryberg E, Rydén-Bergsten T, Smith DM, Korsgren O, Skrtic S, Winzell MS*, Scholz H* (2020) Inhibition of the prostaglandin D2-GPR44/DP2 axis improves human islet survival and function. Diabetologia, 63 (7) (2020), 1355-1367.
• Abadpour, S., A. Aizenshtadt, P. A. Olsen, K. Shoji, S. R. Wilson, S. Krauss, and H. Scholz. Pancreas-on-a-Chip Technology for Transplantation Applications. Curr Diab Rep 20, no. 12 (2020), 72.
• Vethe H, Ghila L, Berle M, Hoareau L, Haaland A, Scholz H, Paulo JA, Chera S, Ræder H. The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation. Front Endocrinol (Lausanne), 10, 293 (2019). DOI 10.3389/fendo.2019.00293, PubMed 31139151
• Schuetz C, Anazawa T, Cross SE, Labriola L, Meier RPH, Redfield RR, Scholz H, Stock PG, Zammit NW, IPITA YIC Young Investigator Committee β Cell Replacement Therapy: The Next 10 Years Transplantation. 102 (2) (2018), 215-229 DOI 10.1097/TP.0000000000001937, PubMed 28885496

Recent publications

• Intercellular communication induces glycolytic synchronization waves between individually oscillating cells. Martin Mojica Benavides, D. D. van Niekerk, M. Mijalkov, J. L. Snoep, Bernhard Mehlig, Giovanni Volpe, Mattias Goksör, Caroline B. Adiels Proceedings of the National Academy of Sciences of the United States of America - 2021-01-01

• Fast and Accurate Nanoparticle Characterization Using Deep-Learning-Enhanced Off-Axis Holography. Benjamin Midtvedt, Erik Olsén, Fredrik Eklund, Fredrik Höök, Caroline B. Adiels, Giovanni Volpe, Daniel Midtvedt ACS Nano - 2021-01-01

• Phosphofructokinase controls the acetaldehyde induced phase shift in isolated yeast glycolytic oscillators.

  David van Niekerk, Anna-Karin Gustavsson, Martin Mojica Benavides, Caroline B. Adiels, Mattias Goksör, Jacky L Snoep The Biochemical journal - 2019-01-01four

• Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform. Amin A Banaeiyan , J. Theobald, Jurgita Paukstyte, S. Wölfl, Caroline B. Adiels, Mattias Goksör Biofabrication 2017-01-01

Recent publications

• Barreby E, Strunz B, Nock S, Naudet L, Shen JX, Johansson H, Sönnerborg I, Ma J, Urgard E, Pallet LJ, Hu Y, Fardellas A, Azzimato V, Vankova A, Levi L, Morgantini C, Maini MK, Stål P, Rosshart SP, Coquet JM, Nowak G, Näslund E, Lauschke VM, Ellis E, Björkström NK, Chen P, Aouadi M. Human resident liver macrophages protect against metabolic stress in obesity. Nature Metabolism 2023 doi: 10.1038/s42255-023-00834-7 [Epub ahead of print]. PMID 37414931.
• Zandi Shafagh R, Youhanna S, Keulen J, Shen JX, Taebnia N, Preiss LC, Klein K, Büttner F, Bergqvist M, van der Wijngaart W, Lauschke VM. Bioengineered pancreas-liver crosstalk in a microfluidic co-culture chip identifies human metabolic response signatures in prediabetic hyperglycemia. Advanced Science 2022 26:e2203368. PMID 36285680.
• Youhanna S, Kemas AM, Preiss L, Zhou Y, Shen JX, Cakal SD, Paqualini FS, Goparaju S, Zandi Shafagh R, Lind JU, Sellgren CM, Lauschke VM. Organotypic and microphysiological human tissue models for drug discovery and development – current state-of-the-art and future perspectives. Pharmacological Reviews 2022 74(1):141-206. PMID 35017176.
• Azzimato V, Chen P, Barreby E, Morgantini C, Levi L, Jager J, Sulen A, Shen JX, Miller A, Ellis E, Ryden M, Näslund E, Thorell A, Lauschke VM, Haschemi A, Craige SM, Mori M, Spallotta F, Aouadi M. Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity. Gastroenterology 2021 161(6):1982-1997. PMID 34425095.
• Shen JX, Couchet M., Dufau J, de Castro Barbosa T, Ulbrich M, Helmstädter M, Kemas AM, Zandi Shafagh R, Marques MA, Hansen J, Mejhert N, Langin D, Ryden M, Lauschke VM. 3D adipose tissue culture links the organotypic microenvironment to improved adipogenesis. Advanced Science 2021 8(16):e2100106. PMID 34165908.

Recent publications

• Matthiesen, I., Voulgaris, D., Nikolakopoulou, P., Winkler, T. E. & Herland, A. (2021) Continuous monitoring reveals protective effects of N-acetylcysteine amide on an isogenic microphysiological model of the neurovascular unit. submitted and posted to bioRxiv(2021). doi:10.1101/2021.03.26.433307

• Nikolakopoulou, P., Rauti, R., Voulgaris, D., Shlomy, I., Maoz, B. M., & Herland, A. (2020). Recent progress in translational engineered in vitro models of the central nervous system. Brain(2020). doi: 1093/brain/awaa268

• Winkler, T. E., Feil, M., Stronkman, E. F. G. J., Matthiesen, I., & Herland, A. (2020). Low-cost microphysiological systems: feasibility study of a tape-based barrier-on-chip for small intestine modeling. Lab on a Chip, 20(7), 1212–1226. doi:10.1039/D0LC00009D
• Herland, A., Maoz, B. M., Das, D., Somayaji, M. R., Prantil-Baun, R., Novak, R., … Ingber, D. E. (2020). Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips. Nature Biomedical Engineering (2020). doi:10.1038/s41551-019-0498-9.
• *Maoz BM, Herland A*, FitzGerald EA, Grevesse T, Vidoudez C, Pacheco AR, Sheehy SP, Park T-E, Dauth S, Mannix R, Budnik N, Shores K, Cho A, Nawroth JC, Segrè D, Budnik B, Ingber DE, Parker KK. A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nature Biotechnology. 2018;36:865-874. doi:10.1038/nbt.4226.

Recent publications

• Andersson, S. Johansson, H. Bergman, L. Xiao, L. Behrendt, M. Tenje. A microscopy-compatible temperature regulation system for single-cell phenotype analysis – demonstrated by thermoresponse mapping of microalgae, Lab on a Chip 21 (2021) 1694-1705
• Raouf Atif, M. Pujari-Palmer, M. Tenje, G. Mestres. A microfluidics-based method for culturing osteoblasts on biomimetic hydroxyapatite, Acta Biomaterialia 127, (2021) 327-337
• Kadekar, L. Barbe, M. Stoddart, O. P. Varghese, M. Tenje, G.Mestres. Effect of the Addition Frequency of 5-Azacytidine in Both Micro- and Macroscale Cultures, Cellular and Molecular Bioengineering 14 (2021) 121–130
• Fornell, H. Pohlit, Q. Shi, M. Tenje. Acoustic focusing of beads and cells in hydrogel droplets, Scientific Reports 11 (2021) 7479
• Paloschi, M. Sabater-Lleal, H. Middelkamp, A. Vivas, S. Johansson, A. van der Meer, M. Tenje, L. Maegdefessel. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases, Cardiovascular Research (2021)